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October 3, 2025Natural Product Research0 citations

Undescribed isoprenoids obtained from Dictamnus dasycarpus Turcz and their cytotoxic activities

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YSYe SunSWSiyi WangYXYang Xu

Key Points

  • Four new isoprenoids were isolated, indicating the potential for novel cytotoxic agents.
  • Compounds 1, 4, 7, 13, and 15 showed cytotoxic effects with IC50 values ranging from 1.55 to 18.55 μM.
  • Techniques like nuclear magnetic resonance spectroscopy were used for structural determination.
  • Findings suggest that dictamnus dasycarpus may yield compounds useful in cancer treatment.

Abstract

Four new isoprenoids, dictamtriterpenols B-E (1-4), and fifteen known compounds (5-19) were isolated from Dictamnus dasycarpus Turcz. And the structures of all compounds were determined through techniques such as nuclear magnetic resonance spectroscopy. Compounds 1, 4, 7, 13, and 15 exhibited notable cytotoxic effects against HepG2 cells (IC50 1.55-18.55 μM). Similarly, compounds 1, 3, 8, 9, and 12 demonstrated significant cytotoxicity against A549 cells (IC50 1.63-8.56 μM).

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Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68dffb0ddaa1363beb04b085https://doi.org/10.1080/14786419.2025.2565265
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