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Peroxisome proliferator-activated receptor delta (PPARD) is a ligand-dependent nuclear transcription factor that regulates a multiplicity of pathophysiological processes vital to cell metabolism. Recent discovery of PPARD overexpressed in villin-positive gastric progenitor cells, demonstrated spontaneous development of large, invasive gastric tumors as the mice aged. These unique animal models allowed us to address the knowledge gap of PPARD-regulated downstream metabolic changes and determine the significance of changes in gastric tumorigenesis by hyperpolarized MRI, NMR spectroscopy and LC-MS. Unlike many cancer systems, we found these gastric cancer tumors are not primarily dependent on aerobic glycolysis but on fatty acid oxidation for energy.
Pudakalakatti et al. (Wed,) studied this question.
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