Key points are not available for this paper at this time.
摘要 心房颤动（AFib）及其致命并发症的风险由纤维化推动，纤维化引起电异质性并产生重入回路。心房TREM2 + 巨噬细胞分泌骨桥蛋白（由Spp1编码），这是一种产生纤维化和心房颤动的基质细胞信号蛋白。我们在此展示，通过抗体-siRNA结合物在TREM2 + 心脏巨噬细胞中沉默Spp1，能够减少小鼠的心房纤维化并抑制心房颤动，从而为最常见的心律失常提供了一种新的免疫疗法。
Published April 23 within past 14 days; rapid uptake with >300 downloads in first week, active discussion on X and ResearchGate among electrophysiologists (estimated 150+ mentions), novel macrophage target generating mechanistic excitement.
Momin等人（周六）研究了这个问题。