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May 16, 2024JAMA Network OpenOpen Access

Comparison of Dual Antiplatelet Therapies for Minor, Nondisabling, Acute Ischemic Stroke: A Bayesian Network Meta-Analysis

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Authors

ALAndy LimHMHenry MaJLJohn Ly

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Overview

Bayesian network meta-analysis compares dual antiplatelet therapies for minor ischemic stroke, suggesting effectiveness of aspirin and ticagrelor.

Key Points

  • DAPT with aspirin and ticagrelor showed a 94% probability of preventing recurrent ischemic stroke at 90 days.
  • Analysis included 5 trials with 28,148 patients; 22,203 had minor strokes, with 63% receiving DAPT.
  • Bayesian network meta-analysis assessed treatment probabilities using surface under the cumulative rank curve (SUCRA). Both DAPT regimens resulted in higher rates of major hemorrhage compared to aspirin alone.

Cite This Study

Lim et al. (2024) studied this question.

synapsesocial.com/papers/68e69b09b6db6435876210cchttps://doi.org/10.1001/jamanetworkopen.2024.11735
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative efficacy and safety of dual antiplatelet therapy strategies defined by drug composition and treatment duration for acute minor ischemic stroke or high-risk transient ischemic attack: A systematic review and Bayesian network meta-analysis2026
  2. 2Ticagrelor plus aspirin in patients with minor ischemic stroke and transient ischemic attack: a network meta-analysis2023 · 7 citations
  3. 3Ticagrelor or dipyridamole plus aspirin may be a promising antiplatelet therapy in patients with minor stroke or transient ischemic attack: a bayesian network meta-analysis2025 · 1 citations
  4. 4Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials2021 · 90 citations
  5. 5P2Y12 Inhibitors Plus Aspirin Versus Aspirin Alone in Patients With Minor Stroke or High-Risk Transient Ischemic Attack2021 · 19 citations