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December 2, 2025Diabetologia12 citationsOpen Access

Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease

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SMSho MatsuiTYTakeshi YamamotoYTYoshitsugu Takabatake

Key Points

  • Ferroptosis risk is heightened with impaired autophagy in diabetic kidney disease leading to significant kidney injury.
  • Key focus on therapeutic strategies targeting autophagy and AMPK activation to mitigate susceptibility to ferroptosis.
  • Analysis of mechanisms linking autophagy deficits and AMPK inactivation to kidney damage in individuals with diabetes.
  • Study highlights the critical need for targeted interventions to address ferroptosis-associated renal injury in diabetic patients.

Abstract

These findings demonstrate that impaired autophagy and inactivated AMPK heighten susceptibility to ferroptosis in DKD, suggesting that therapeutic strategies targeting autophagy and AMPK activation may reduce ferroptosis-associated kidney injury in individuals with diabetes.

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Cite This Study

Matsui et al. (2025) studied this question.

synapsesocial.com/papers/692e3da16c9b3ab28c187ce6https://doi.org/10.1007/s00125-025-06612-2
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