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December 4, 2025Stem Cell Research & Therapy0 citationsOpen Access

Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy

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HKHaiyang KouWZWeijie ZhangJMJianbing Ma

Key Points

  • Curcumin enhances therapeutic effects in osteoarthritis by controlling senescence in stem cells, indicating its potential utility.
  • The most significant mechanism observed was autophagy regulation linked to FoxO3 signaling affecting stem cell behavior.
  • Assessment using curcumin-pretreated adipose-derived mesenchymal stem cells delivered via intra-articular injection for joint health.
  • This highlights curcumin's potential in osteoarthritis treatment but calls for further studies on clinical efficacy.

Abstract

Curcumin controls ADSC senescence via the FoxO3-mediated signaling pathway, and FoxO3 directly regulates Becnl to induce autophagy. Intra-articular injection of curcumin-pretreated ADSCs enhances joint homeostasis for OA treatment. This study provides evidence for the potential clinical application of curcumin-pretreated ADSCs in enhancing the therapeutic effects of OA treatment.

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Cite This Study

Kou et al. (2025) studied this question.

synapsesocial.com/papers/6930dc5fea1aef094cca1cb5https://doi.org/10.1186/s13287-025-04836-y
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