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December 6, 2025European Journal of Nuclear Medicine and Molecular Imaging4 citationsOpen Access

Molecular imaging of fibroblast activation in systemic sclerosis using 18FAlF-NOTA-FAPI-04 PET/CT: a prospective cohort study

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MWMeng WangZWZeyang WangYWYi Wu

Key Points

  • Noninvasive imaging approach maps fibroblast activation across multiple organs in systemic sclerosis, with implications for metabolism.
  • It demonstrated potential for detecting fibrotic burden and profiling organ metabolism systematically in a clinical setting.
  • Analysis involved prospective cohort study methodology to evaluate [18F]AlF-NOTA-FAPI-04 PET/CT imaging effectiveness.
  • Sensitivity remains limited in gastrointestinal and cutaneous involvement, highlighting the need for further optimization.

Abstract

¹⁸FAlF-NOTA-FAPI-04 PET/CT provides a noninvasive, integrative imaging platform for mapping fibroblast activation across multiple organs in SSc. It demonstrated potential for detection of fibrotic burden and inter-organ metabolic profiling. Its sensitivity in gastrointestinal and cutaneous involvement remains limited, warranting further optimization.

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/694020f72d562116f28fb3d8https://doi.org/10.1007/s00259-025-07586-4
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