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Prospective cohort study shows fibroblast activation in systemic sclerosis, suggesting improved detection of fibrotic burden.
[¹⁸F]AlF-NOTA-FAPI-04 PET/CT provides a noninvasive, integrative imaging platform for mapping fibroblast activation across multiple organs in SSc. It demonstrated potential for detection of fibrotic burden and inter-organ metabolic profiling. Its sensitivity in gastrointestinal and cutaneous involvement remains limited, warranting further optimization.
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Wang et al. (2025) studied this question.
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