Hyperoside, a dietary flavonoid, protects against endometritis via gut microbiota-dependent production of hydroxyphenyllactic acid and the gut–uterus axis

Dietary hyperoside enriches gut Lactobacillus , boosting the metabolite HPLA. Circulating HPLA targets uterine TLR4, suppressing TLR4/NF-κB signaling and alleviating endometrial inflammation and damage.