What does this research mean for the field?

The monocyte-to-HDL cholesterol ratio (MHR) is a significant predictor of the severity of obstructive sleep apnea syndrome (OSAS), with higher MHR levels associated with more severe cases. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study explores the correlation between the monocyte-to-HDL cholesterol ratio and the severity of obstructive sleep apnea syndrome.

January 10, 2026Medicine0 citationsOpen Access

Elevated monocyte-to-HDL cholesterol ratio predicts severity of obstructive sleep apnea syndrome

AAAbass Mahamoud AhmedYangzhou University SNSalman Mohamud NurYangzhou University LLLi LiDalian Medical University

Key Result

The monocyte-to-HDL cholesterol ratio (MHR) was significantly higher in severe OSAS (10.7) compared to control (8.6) and earlier stages of OSAS (9.1-9.2).

Key Points

The study explores the correlation between the monocyte-to-HDL cholesterol ratio and the severity of obstructive sleep apnea syndrome.
Retrospective analysis of 391 subjects, including controls and OSAS patients.
Subjects were categorized by OSAS severity: mild, moderate, and severe.
Statistical analysis performed using IBM SPSS software version 26.0.
Significant differences in MHR levels observed across OSAS severity groups.
Mean MHR level for severe OSAS was 10.7, compared to 8.6 in the control group.
MHR increased with higher apnea-hypopnea index values, highlighting its predictive capacity.

Structured PICO

Does the monocyte-to-HDL cholesterol ratio predict the incidence and severity of obstructive sleep apnea syndrome?

Population

391 subjects, including 102 control without OSAS and 298 with OSAS (84 mild, 98 moderate, and 107 severe)

Comparator

Control group without OSAS

Outcome

Correlation between the monocyte-to-HDL cholesterol ratio (MHR) and obstructive sleep disorders/severitysurrogate

Elevated monocyte-to-HDL cholesterol ratio is associated with increased severity of obstructive sleep apnea syndrome and may serve as a clinical predictor.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Obstructive sleep apnea syndrome (OSAS) presents with various cues and symptoms such as witnessed apneas, excessive daytime sleepiness, and snoring. However, these symptoms are not exclusive to OSAS and can be indicative of a spectrum of sleep disorders. Despite its global prevalence, there lacks a clinical predictor for determining OSAS incidence and severity. This study aims to explore the correlation between the monocyte-to-HDL cholesterol ratio (MHR) and obstructive sleep disorders, thereby eslishing a predictive framework for OSAS and its severity in clinical settings. The study included a total of 391 subjects, including 102 control and 298 OSAS group. The control was determined not to have OSAS, while the OSAS group was further divided based on the severity of the OSAS, including (84 mild, 98 moderate, and 107 severe). The study was conducted retrospectively, and statistical analysis was performed using IBM SPSS statistical software version 26.0. The difference was statistically significant in the levels of MHR, body mass index, blood lipids (triglyceride (Tg)), blood glucose (Glu), Total WBC, Monocytes, Hemoglobin, ALT, creatinine, uric acid and polysomnographic (PG) parameters (apnea–hypopnea index, minimal SpO 2 ) in the OSAS group ( P < .05). The MHR level for the severe OSAS group was 10.7, which was higher than the control (8.6), mild OSAS (9.2), and moderate OSAS (9.1). Additionally, the value of MHR levels was significantly higher in patients with hypertension and coronary heart diseases. The study revealed that the monocyte-to-HDL ratio (MHR) was shown to increase with the apnea–hypopnea index, which emphasizes its utility as a predictor of OSAS.

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