The homozygous mutant GG genotype of MGAT1 SNP rs634501 increased hypertension risk, while the T allele of KLK2 SNP rs198972 decreased it in the Dong population.
Are specific single nucleotide polymorphisms (SNPs) in candidate genes associated with an increased risk of hypertension in the Dong ethnic population of Tongdao?
The MGAT1 gene (specifically SNP rs634501) is identified as a potential susceptibility gene for hypertension in the Dong ethnic population.
This study aimed to identify susceptibility genes of hypertension in Tongdao Dong ethnic group. 38 hypertension candidate genes with their 42 single nucleotide polymorphisms (SNPs) screened from our previous study were selected for genotyping using MALDI-TOF mass spectrometry in a total of 359 participants, including 242 hypertensive patients and 117 healthy controls. The genotype and allele frequencies of these 42 SNPs were compared between the normotensive and hypertensive groups. 7 SNPs (KLK2 rs198972, MGAT1 rs634501, ABCA1 rs2066714, ADRB1 rs1801253, CLCN2 rs2228291, FOLH1 rs202680, and SCNN1G rs5735) exhibiting significant differences in genotypic and/or allelic frequencies between the two groups were subsequently selected for hypertension risk analysis. Logistic regression analysis with adjustment for the same factors revealed that the homozygous mutant GG genotype of MGAT1 SNP rs634501 enhanced the risk of hypertension, whereas carriers of the T minor allele of KLK2 SNP rs198972 showed a decreased risk of hypertension. Association analysis of SNPs with hypertension-related risk factors showed that MGAT1 rs634501 was significantly associated with SBP and DBP. Thus, our study suggests that MGAT1 may be a susceptibility gene for hypertension in the Dong Ethnic Population of Tongdao.
Zhou et al. (2026) studied this question. The homozygous mutant GG genotype of MGAT1 SNP rs634501 increased hypertension risk, while the T allele of KLK2 SNP rs198972 decreased it in the Dong population.