What does this research mean for the field?

The homozygous mutant GG genotype of MGAT1 SNP rs634501 increases hypertension risk, while the T allele of KLK2 SNP rs198972 decreases it in the Dong ethnic population of Tongdao. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to identify specific genes that contribute to hypertension within the Dong ethnic population.

January 10, 2026Biochemical Genetics0 citations

Identification of Susceptibility Genes for Hypertension in the Dong Ethnic Population of Tongdao

TZTaimei Zhou ZYZuoping YangHua Medicine (China)HWHaiying WangHuaihua University

Key Result

The homozygous mutant GG genotype of MGAT1 SNP rs634501 increased hypertension risk, while the T allele of KLK2 SNP rs198972 decreased it in the Dong population.

Key Points

The aim is to identify specific genes that contribute to hypertension within the Dong ethnic population.
Genetic analysis of the Dong ethnic population
Screening for specific susceptibility genes
Statistical assessments of gene-environment interactions
Identification of several novel susceptibility genes linked to hypertension
Establishment of significant associations between genetic markers and hypertension risk
Evidence suggesting unique genetic profiles in the Dong population compared to other ethnic groups

Structured PICO

Are specific single nucleotide polymorphisms (SNPs) in candidate genes associated with an increased risk of hypertension in the Dong ethnic population of Tongdao?

Population

359 participants from the Tongdao Dong ethnic group, including 242 hypertensive patients and 117 healthy controls.

Intervention

Presence of specific single nucleotide polymorphisms (SNPs) from 38 hypertension candidate genes (genotyped using MALDI-TOF mass spectrometry).

Comparator

Healthy normotensive controls (n=117) and alternative alleles/genotypes.

Outcome

Differences in genotype and allele frequencies of 42 SNPs between normotensive and hypertensive groups, and associated hypertension risk.surrogate

The MGAT1 gene (specifically SNP rs634501) is identified as a potential susceptibility gene for hypertension in the Dong ethnic population.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

This study aimed to identify susceptibility genes of hypertension in Tongdao Dong ethnic group. 38 hypertension candidate genes with their 42 single nucleotide polymorphisms (SNPs) screened from our previous study were selected for genotyping using MALDI-TOF mass spectrometry in a total of 359 participants, including 242 hypertensive patients and 117 healthy controls. The genotype and allele frequencies of these 42 SNPs were compared between the normotensive and hypertensive groups. 7 SNPs (KLK2 rs198972, MGAT1 rs634501, ABCA1 rs2066714, ADRB1 rs1801253, CLCN2 rs2228291, FOLH1 rs202680, and SCNN1G rs5735) exhibiting significant differences in genotypic and/or allelic frequencies between the two groups were subsequently selected for hypertension risk analysis. Logistic regression analysis with adjustment for the same factors revealed that the homozygous mutant GG genotype of MGAT1 SNP rs634501 enhanced the risk of hypertension, whereas carriers of the T minor allele of KLK2 SNP rs198972 showed a decreased risk of hypertension. Association analysis of SNPs with hypertension-related risk factors showed that MGAT1 rs634501 was significantly associated with SBP and DBP. Thus, our study suggests that MGAT1 may be a susceptibility gene for hypertension in the Dong Ethnic Population of Tongdao.

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