What question did this study set out to answer?

To determine whether the A1166C polymorphism of the angiotensin II type 1 receptor (AT1R) gene is associated with essential hypertension across Han, Tibetan, and Yi populations in China.

January 1, 2002Hypertension ResearchOpen Access

A1166C Polymorphism of the Angiotensin II Type 1 Receptor Gene and Essential Hypertension in Han, Tibetan and Yi Populations.

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Why the study?

Is the A1166C polymorphism of the AT1R gene associated with essential hypertension in Han, Tibetan, and Yi populations?

Population

748 subjects (302 normotensive and 446 hypertensive) from Han, Tibetan, and Yi populations in China

Comparison

A1166C polymorphism of the angiotensin II type 1… vs Normotensive controls

Design

Case-control

Authors

YLYing LiuInner Mongolia University of Science and Technology CZCiren ZhuomaSichuan University GSGuangliang ShanChinese Academy of Medical Sciences & Peking Union Medical College

Discussion

Member takes

Implication

AA genotype may raise hypertension risk in Tibetan males only; hypothesis-generating and requires prospective validation across populations.

Key Points

To determine whether the A1166C polymorphism of the angiotensin II type 1 receptor (AT1R) gene is associated with essential hypertension across Han, Tibetan, and Yi populations in China.
Enrolled 302 normotensive controls and 446 hypertensive patients across Han, Tibetan, and Yi ethnic groups.
Genotyped the A1166C polymorphism using genomic DNA polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).
Analyzed genetic associations and hypertension risk factors using chi-square tests, ANCOVA, and multiple logistic regression.
The A1166 allele frequency was significantly higher in Tibetan male hypertensives compared to normotensive controls (X2=11.46, p=0.001), while no significant differences in genotype distribution or allele frequency were observed in Han (p=0.465) or Yi (p=0.357) cohorts.
The AA genotype was an independent risk factor for hypertension specifically in Tibetan males (p=0.0034), with Tibetan men carrying the AA genotype displaying significantly higher diastolic blood pressure than those carrying AC or CC genotypes (p=0.0040).
Baseline A1166 allele frequencies among normotensive controls were 0.979 (Han), 0.939 (Tibetan), and 0.965 (Yi), showing no significant intergroup variation (X2=4.166, p=0.125).

Structured PICO

Is the A1166C polymorphism of the AT1R gene associated with essential hypertension in Han, Tibetan, and Yi populations?

Population

748 subjects (302 normotensive and 446 hypertensive) from Han, Tibetan, and Yi populations in China

Intervention

A1166C polymorphism of the angiotensin II type 1 receptor (AT1R) gene

Comparator

Normotensive controls

Outcome

Susceptibility to essential hypertension (allele frequency and genotype distribution)

The A1166 allele of the AT1R gene may predispose Tibetan males to essential hypertension, but it does not appear to be involved in the pathogenesis of hypertension in Han or Yi populations.

Cite This Study

Liu et al. (2002) studied this question.

synapsesocial.com/papers/6a8be3de039371f2a389715c https://doi.org/10.1291/hypres.25.515

Topics

Hypertension management

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Implication

AA genotype may raise hypertension risk in Tibetan males only; hypothesis-generating and requires prospective validation across populations.

A1166C Polymorphism of the Angiotensin II Type 1 Receptor Gene and Essential Hypertension in Han, Tibetan and Yi Populations.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A1166C Polymorphism of the Angiotensin II Type 1 Receptor Gene and Essential Hypertension in Han, Tibetan and Yi Populations.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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