Association of the Angiotensin II Type 1 Receptor A1166C Polymorphism with Essential Hypertension in the Chinese Population: A Meta-Analysis with Ethnic and Geographic Subgroup Analyses

Q: What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Essential hypertension (n=13707). Intervention: AT1R A1166C gene polymorphism vs. Healthy controls. Primary outcome: Susceptibility to essential hypertension (p=0.04).

Q: What does this research mean for the field?

The AT1R A1166C gene polymorphism modestly contributes to essential hypertension susceptibility in the Chinese population, with this association partly influenced by ethnic and regional factors. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jun Gu; Li Shi; Weidong Ren; Z N Xu; Wenjuan Deng; Limei Hu; Huiying Liu; Zhiying Zhang; Gaijun Ning; Yu Cai

doi:10.1080/08037051.2026.2676370

May 20, 2026Blood PressureOpen Access

Association of the Angiotensin II Type 1 Receptor A1166C Polymorphism with Essential Hypertension in the Chinese Population: A Meta-Analysis with Ethnic and Geographic Subgroup Analyses

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Key result

AT1R A1166C polymorphism is linked to modestly higher essential hypertension risk in Chinese populations.

P=0.04
n=13,707

Why the study?

To explore the association between the angiotensin II type 1 receptor A1166C gene polymorphism and susceptibility to essential hypertension within the Chinese population.

Is the angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism associated with susceptibility to essential hypertension in the Chinese population?

Key Points

This research investigates the relationship between the AT1R A1166C polymorphism and essential hypertension in the Chinese population.
Performed a meta-analysis including 17 studies with 9,213 patients having essential hypertension and 4,494 healthy controls.
Conducted subgroup analyses by ethnicity and region, as well as sensitivity analyses and assessment of publication bias.
Literature was collected from various sources up to December 31, 2024.
The meta-analysis indicates a statistically significant association (p=0.04) between the AT1R A1166C polymorphism and increased susceptibility to essential hypertension.
Subgroup analyses reveal varied effects based on ethnic and regional factors, though these findings need cautious interpretation.
Publication bias assessment shows low levels of bias in the included studies.

Study Design

Type

Meta-Analysis (n=13,707)

Structured PICO

Is the angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism associated with susceptibility to essential hypertension in the Chinese population?

P

Population

13,707 individuals from the Chinese population across 17 studies, comprising 9,213 patients with essential hypertension (EH) and 4,494 healthy controls.

I

Intervention

Presence of the angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism

C

Comparator

Healthy controls (absence of essential hypertension)

O

Outcome

Susceptibility to essential hypertension (EH)

Main Result

p-value: p=0.04

The AT1R A1166C gene polymorphism may modestly increase susceptibility to essential hypertension in the Chinese population, though regional and ethnic factors influence this association.

Limitations

Subgroup findings should be interpreted cautiously
Need for more balanced subgroup representations
Need for standardised blood pressure assessment methods

Implication

May guide genetic risk stratification for EH in Chinese patients; leaves open causal validation and clinical utility.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Gu et al. (2026) conducted a meta-analysis in Essential hypertension (n=13,707). AT1R A1166C gene polymorphism vs. Healthy controls was evaluated on Susceptibility to essential hypertension (p=0.04). The AT1R A1166C polymorphism may modestly contribute to essential hypertension susceptibility in the Chinese population (P=0.04).

synapsesocial.com/papers/6a0ff496d674f7c03778db65 https://doi.org/10.1080/08037051.2026.2676370

Topics

Hypertension management

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Association of the Angiotensin II Type 1 Receptor A1166C Polymorphism with Essential Hypertension in the Chinese Population: A Meta-Analysis with Ethnic and Geographic Subgroup Analyses

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Discussion

Cite This Study

Topics

Association of the Angiotensin II Type 1 Receptor A1166C Polymorphism with Essential Hypertension in the Chinese Population: A Meta-Analysis with Ethnic and Geographic Subgroup Analyses

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Discussion

Cite This Study

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Topics

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