Key result
The A1166C polymorphism in the AT1R gene was associated with a statistically increased risk of hypertension in Asian and Caucasian populations across 56 studies involving 28,952 subjects.
Why the study?
Is the AT1R gene A1166C polymorphism associated with an increased risk of hypertension?
Meta-Analysis (n=28,952)
Is the AT1R gene A1166C polymorphism associated with an increased risk of hypertension?
The AT1R A1166C polymorphism is a genetic risk factor for hypertension in Asian and Caucasian populations.
Supports AT1R A1166C as hypertension risk marker in Asians/Caucasians; leaves open clinical utility pending prospective validation.
BACKGROUND: Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension. METHODS: We searched the literature in PubMed, EMBASE, ISI Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases (CNKI) to find case-control studies on the associations of AT1R genetic polymorphisms with the risk for hypertension. The meta-analysis was performed by using RevMan 5.0 software. The association of hypertension risk with AT1R genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Fifty-six studies involving 28,952 subjects were included in the present meta-analysis. Our results suggest that the polymorphism (A1166C) of AT1R gene is associated with a statistically increased hypertension risk, not only in Asian populations but also in Caucasian populations. We did not find any association in African populations. CONCLUSIONS: This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations.
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Liu et al. (2015) conducted a meta-analysis in Hypertension (n=28,952). AT1R A1166C polymorphism was evaluated on Hypertension risk. The A1166C polymorphism in the AT1R gene was associated with a statistically increased risk of hypertension in Asian and Caucasian populations across 56 studies involving 28,952 subjects.
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