Key result
The AT1R-A1166C polymorphism AC/CC genotypes were associated with a significantly increased risk of coronary heart disease in East Asian populations compared to the AA genotype (OR 1.57; 95% CI 1.16-2.13).
Why the study?
Does the AT1R-A1166C polymorphism increase the risk of coronary heart disease in the East Asian population?
Meta-Analysis (n=4,780)
Does the AT1R-A1166C polymorphism increase the risk of coronary heart disease in the East Asian population?
Odds Ratio: 1.57 (95% CI 1.16–2.13)
The AT1R-A1166C polymorphism (C allele and AC/CC genotypes) is associated with a significantly increased risk of coronary heart disease in East Asian populations.
May inform CHD risk assessment in East Asians; leaves open prospective validation before clinical adoption.
UNLABELLED: Angiotensin II type 1 receptor (AT1R) mediates the cardiovascular actions of angiotensin II. Growing studies have revealed the underlying association between AT1R-A1166C (rs5186) polymorphism and coronary heart disease (CHD) among the East Asia population. RESULTS: from these studies remain conflicting. We conducted this meta-analysis to estimate the overall CHD risk of AT1R-A1166C polymorphism regarding the East Asia population. We searched the PubMed, Embase and China National Knowledge Infrastructure (CNKI) databases for all articles within a range of published years from 1995 to 2011. The odds ratio (OR) corresponding to the 95% confidence interval (CI) was used to assess the different associations. The statistical heterogeneity among studies was assessed with the Q-test and I (2) statistics. Up to December 2011, 17 case-control studies, including 2,366 cases and 2,414 controls, were available for our study. The C allele and the AC/CC genotypes were associated with significantly increased risk of CHD (OR = 1.59, 95% CI = 1.22-2.06 for C versus A and OR = 1.57, 95% CI = 1.16-2.13 for AC/CC versus AA, respectively). Our result suggested that AT1R-A1166C polymorphism may be involved in the development of CHD.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2012) conducted a meta-analysis in Coronary heart disease (CHD) (n=4,780). AT1R-A1166C (rs5186) polymorphism (AC/CC genotypes) vs. AA genotype was evaluated on Risk of coronary heart disease (OR 1.57, 95% CI 1.16-2.13). The AT1R-A1166C polymorphism AC/CC genotypes were associated with a significantly increased risk of coronary heart disease in East Asian populations compared to the AA genotype (OR 1.57; 95% CI 1.16-2.13).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: