April 1, 2010Asian BiomedicineOpen Access

Association between angiotensin II type-1 receptor A1166C polymorphism and the presence of angiographically-defined coronary artery disease in an Iranian population

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Why the study?

Does the AT1R/A1166C polymorphism increase the risk of angiographically-defined coronary artery disease in an Iranian population?

Population

548 subjects in an Iranian population, comprising 413 patients with suspected CAD undergoing coronary…

Comparison

Presence of the AT1R/A1166C polymorphism vs Absence of the polymorphism and healthy control…

Design

Case-control

Authors

AAAkram AssaliMashhad University of Medical Sciences JBJavad BehravanMashhad University of Medical Sciences RPRoghayeh PaydarMashhad University of Medical Sciences

Discussion

Member takes

Implication

Does not support AT1R/A1166C as CAD risk marker in Iranians; challenges prior associations and leaves population validation open.

Structured PICO

Does the AT1R/A1166C polymorphism increase the risk of angiographically-defined coronary artery disease in an Iranian population?

Population

548 subjects in an Iranian population, comprising 413 patients with suspected CAD undergoing coronary angiography (CAD+ n=315 with >50% stenosis, CAD- n=98 with <50% stenosis) and 135 healthy volunteers as controls.

Intervention

Presence of the AT1R/A1166C polymorphism (AC and CC genotypes, C allele)

Comparator

Absence of the polymorphism (AA genotype, A allele) and healthy control group

Outcome

Presence of angiographically-defined coronary artery disease (>50% stenosis of any major coronary artery)surrogate

Limitations

CAD- subjects with <50% stenosis might progress to overt CAD over time
CAD- subjects were significantly younger than CAD+ patients
Complex nature of gene-environment interactions
Involvement of multiple genes in CAD pathophysiology makes it difficult to identify a single polymorphism as a risk factor

Cite This Study

Assali et al. (2010) studied this question.

synapsesocial.com/papers/6a2071daa40bcbc79e09917a https://doi.org/10.2478/abm-2010-0038

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Association between angiotensin II type-1 receptor A1166C polymorphism and the presence of angiographically-defined coronary artery disease in an Iranian population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Association between angiotensin II type-1 receptor A1166C polymorphism and the presence of angiographically-defined coronary artery disease in an Iranian population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider