Why the study?
Does ACE inhibition modify the effect of the AT1R A1166C gene polymorphism on angiotensin II responsiveness in isolated human arteries?
Does ACE inhibition modify the effect of the AT1R A1166C gene polymorphism on angiotensin II responsiveness in isolated human arteries?
The AT1R A1166C gene polymorphism is associated with increased angiotensin II responsiveness in human arteries, which is preserved even during ACE inhibition.
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C/C homozygotes retain angiotensin II hyperresponsiveness despite ACE inhibition; extends pharmacogenetic stratification for hypertension trials.
Geel et al. (2000) studied this question.
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