Key result
The frequency of the AT1R gene A1166C polymorphism was significantly higher in patients with familial hypertension compared to healthy adults (p=0.020).
Why the study?
Is the AT1R gene A1166C polymorphism associated with familial primary hypertension in the Han Chinese population?
Case-Control (n=432)
No
Is the AT1R gene A1166C polymorphism associated with familial primary hypertension in the Han Chinese population?
p-value: p=0.020
The A1166C polymorphism of the AT1R gene is associated with familial hypertension in the Han Chinese population, independent of age or gender.
Supports genetic association in Han Chinese familial hypertension; hypothesis-generating and requires prospective validation before any clinical use.
OBJECTIVE: To study the polymorphism of angiotensin-type 1 receptor (AT1R) gene A1166C in familial primary hypertension and its distribution in Han Yellow race of China. METHODS: One hundred and four hypertensive patients with no family history, 178 hypertensive patients with familial history, and 150 healthy adults were randomly selected to participate in a prospective clinical trial, and genetype detection by standard polymerase chain reaction methods and restriction fragment length polymorphism (PCR-RFLP) in trials. The study was carried out between October 2009 and November 2010 at Jinan Center for Cardiovascular Disease, Affiliated Hospital of Taishan Medical College, Jinan, China. RESULTS: Notable statistical significances exist in the frequency of genotype and allele of A1166C in familial hypertension group (x2=7.663, p=0.020) compared with the normal control group (x2= 8.288, p=0.004). No significant difference was found in the hypertension group (x2 = 2.186, p=0.322) compared with the normal control group (x2=1.289, p=0.256) in the frequency of genotype and allele of A1166C. No significant differences were found between various ages or genders in each of the 3 groups in genotype and allele of A1166C (p>0.05) distribution. CONCLUSION: In the Han Yellow race population of China, the frequency of genotype and allele of A1166C of patients with familial hypertension is higher than that of healthy adults. The distribution of AT1R gene polymorphisms of A1166C is not related to age or gender.
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Jin-min et al. (2013) conducted a case-control in familial primary hypertension (n=432). Angiotensin-type 1 receptor (AT1R) gene A1166C polymorphism vs. Healthy adults was evaluated on Frequency of genotype and allele of A1166C (p=0.020). The frequency of the AT1R gene A1166C polymorphism was significantly higher in patients with familial hypertension compared to healthy adults (p=0.020).
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