Does sulcardine sulfate alter electrocardiographic intervals and demonstrate safety in healthy volunteers?
Intravenous sulcardine sulfate is well tolerated in healthy volunteers and produces dose-dependent ECG changes consistent with multi-ion channel blockade, including JTpc shortening which may mitigate proarrhythmic risk.
Sulcardine increased the QTc and PR intervals, QRS and P-wave durations, and HR dose dependently. The T-wave segment JTpc was significantly decreased, whereas the T peak to T end interval was significantly increased. These findings predict an anti-atrial fibrillation effect via inhibition of 1 or more cardiac ion channels. The strong block of the rapid component of the delayed rectifier potassium channel current was partially mitigated by JTp shortening, probably owing to late sodium current and L-type calcium current inhibition, reducing the risk of proarrhythmia by decreasing repolarization time.
Mason et al. (Thu,) studied this question.