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January 10, 2026Cell stem cell0 citations

Reverse engineering the beat: Assembloid modeling of sympathetic control of the heart

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JNJunsung NamRSRoy C. SimamoraFBFikri Birey

Key Points

  • This research aims to explore how sympathetic signals influence heart activity through innovative assembloid modeling techniques.
  • Developed assembloid models to mimic heart and neural interactions

Structured PICO

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Population
in vitro human sympathetic ganglion organoids assembled with heart-forming organoids

The creation of sympathetic-cardiac assembloids offers a new in vitro model for studying autonomic neuromodulation and cardiometabolic diseases.

Abstract

Liu et al.1 generate human sympathetic ganglion organoids and assemble them with heart-forming organoids to build functionally connected sympathetic-cardiac organoids in vitro. Their platform captures autonomic development, neuromodulation of heart function, and metabolic injury, opening new opportunities to study human autonomic disorders and cardiometabolic disease.2.

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Cite This Study

Nam et al. (2026) studied this question.

synapsesocial.com/papers/6963220391e05aa366cb8643https://doi.org/10.1016/j.stem.2025.12.012
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