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Reverse engineering the beat: Assembloid modeling of sympathetic control of the heart | Synapse

January 10, 2026Cell stem cell0 citations

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Reverse engineering the beat: Assembloid modeling of sympathetic control of the heart

JNJunsung NamEmory University RSRoy C. SimamoraEmory University FBFikri BireyEmory University

Key Points

This research aims to explore how sympathetic signals influence heart activity through innovative assembloid modeling techniques.
Developed assembloid models to mimic heart and neural interactions

Structured PICO

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Population

in vitro human sympathetic ganglion organoids assembled with heart-forming organoids

The creation of sympathetic-cardiac assembloids offers a new in vitro model for studying autonomic neuromodulation and cardiometabolic diseases.

Abstract

Liu et al.1 generate human sympathetic ganglion organoids and assemble them with heart-forming organoids to build functionally connected sympathetic-cardiac organoids in vitro. Their platform captures autonomic development, neuromodulation of heart function, and metabolic injury, opening new opportunities to study human autonomic disorders and cardiometabolic disease.2.

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Cite This Study

Nam et al. (Thu,) studied this question.

synapsesocial.com/papers/6963220391e05aa366cb8643 https://doi.org/https://doi.org/10.1016/j.stem.2025.12.012