Key result
Neurocardiac digital twin predicts autonomic proarrhythmia triggers and models neuromodulation to terminate arrhythmias.
Why the study?
Autonomic imbalance is implicated in arrhythmias and heart failure, but understanding the mechanisms of autonomic stimulation is challenging because synapses across different cardiac regions induce multiple changes in function.
A novel multiscale digital twin framework successfully simulates neurocardiac modulation, offering a predictive tool for testing neuromodulatory therapies for arrhythmias.
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May inform neuromodulation strategies for arrhythmias; leaves open validation in human studies.
Yang et al. (2023) studied Arrhythmias. Multiscale neurocardiac digital twin was evaluated. A multiscale neurocardiac digital twin predicted conditions under which autonomic imbalance induces proarrhythmia and demonstrated how neuromodulation may be used to terminate arrhythmias.
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