Key result
Stem cell-derived heart valve models recreate key aspects of valve development, tissue organization, and disease, providing new platforms to investigate disease mechanisms and therapies.
Discusses the advent of accessible human stem cell-derived heart valve models that open new avenues for investigating disease mechanisms and therapies.
Heart valve research has long lacked accessible human model systems. In this issue of Cell Stem Cell, He et al. and Voges et al. introduce complementary stem cell-derived valve models that recreate key aspects of valve development, tissue organization, and disease, opening new avenues to investigate disease mechanisms and therapies.
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Porras et al. (2026) studied this question. Stem cell-derived heart valve models recreate key aspects of valve development, tissue organization, and disease, providing new platforms to investigate disease mechanisms and therapies.
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