Direct oral anticoagulants combined with antiplatelet in the treatment of acute coronary syndrome and atrial fibrillation patients undergoing percutaneous coronary intervention or complicating acute coronary syndrome: a systematic review and meta-analysis

Key Result

Combining DOACs with antiplatelets requires a tailored approach to balance ischemic and bleeding risks in ACS and AF patients undergoing PCI.

Key Points

• This research aims to evaluate the combined use of direct oral anticoagulants and antiplatelet therapy in patients with acute coronary syndrome and atrial fibrillation.
• Conducted a systematic review and meta-analysis.
• Focused on patients undergoing percutaneous coronary intervention and those with complicating acute coronary syndrome.
• Assessed the balance between ischemic and bleeding risks.
• Indicated a favorable outcome for high ischemic risk patients with low bleeding risk.
• Highlighted the necessity for tailored treatment regimens based on individual patient risk profiles.