What question did this study set out to answer?

This research aims to determine the predictive value of the HELT-E2S2 score for clinical outcomes following catheter ablation in atrial fibrillation patients.

January 10, 2026Circulation Reports1 citationsOpen Access

Predictive Value of the HELT-E2S2 Score for Clinical Outcomes After Catheter Ablation for Atrial Fibrillation　― Subanalysis of the Shinshu Catheter Ablation (Shinshu-AB) Registry ―

KTK TanakaShinshu University AOAyako OkadaShinshu University MMMasatoshi MinamisawaHeart Failure / Cardiomyopathy

Key Points

This research aims to determine the predictive value of the HELT-E2S2 score for clinical outcomes following catheter ablation in atrial fibrillation patients.
Conducted a subanalysis of the Shinshu Catheter Ablation Registry.

Structured PICO

Does a higher HELT-E2S2 score predict an increased risk of atrial fibrillation recurrence in patients undergoing first-time catheter ablation?

Population

769 Japanese patients (median age 70 years, 31.2% female) with atrial fibrillation (40.8% persistent) undergoing first-time catheter ablation, enrolled in the multicenter Shinshu-AB Registry.

Intervention

Risk stratification using the HELT-E2S2 score (categorized into 0, 1, 2, and ≥3 points) prior to first-time catheter ablation for atrial fibrillation.

Comparator

Patients with a HELT-E2S2 score of 0 (Group 1).

Outcome

Atrial fibrillation recurrence after catheter ablation beyond the 3-month blanking period during a 1-year follow-up.

The HELT-E2S2 score, originally developed for stroke risk assessment, is a significant independent predictor of atrial fibrillation recurrence after first-time catheter ablation.

Abstract

Higher HELT-E2S2 scores were associated with an increased risk of AF recurrence after CA.

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