Mn²⁺-Coordinated Glycyrrhizic Acid Self-Adjuvating Hydrogel for Sustained Codelivery of Antigen and Mn²⁺ for a Potent Immune Response

Key Points

• To develop a self-adjuvating hydrogel that supports the codelivery of antigens and adjuvants for an immune response.
• Constructed a self-adjuvating hydrogel using Mn²⁺ and Glycyrrhizic Acid through self-assembly.
• Evaluated sustained codelivery of antigens and Mn²⁺.
• Investigated immune response elicited by the hydrogel.
• The hydrogel induced a significantly enhanced immune response.
• Sustained codelivery of antigens and Mn²⁺ was observed.