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January 17, 2026RSC Medicinal Chemistry0 citations

Exploring Pyrazoline-Thiophene Hybrids as CDK2 Inhibitors: Synthesis, Mechanistic, Biological Studies, and Computational Insights

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HAHeba M. AbosalimTETarek ElmoselhyNSNabaweya Sharafeldin

Key Points

  • This research aims to synthesize and evaluate the anticancer properties of pyrazoline-thiophene hybrids.
  • Synthesis of pyrazoline-linked thiophene compounds.
  • Assessment of anticancer potential through biological studies.
  • Evaluation of mechanistic pathways influencing efficacy.
  • Computational modeling to predict interactions with CDK2.
  • Identified bis-thiophene compounds (4n and 4o) as the most effective analogues.
  • Tris-thiophene compound (4p) also showed significant anticancer activity.
  • Mechanistic studies revealed insights into pathways affected by these compounds.

Abstract

Pyrazoline-linked thiophene (4a-p), a novel family of compounds, was designed and synthesized, and its anticancer potential was assessed. The most effective analogues of bis-thiophene (4n and 4o) and tris-thiophene (4p)...

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Cite This Study

Abosalim et al. (2026) studied this question.

synapsesocial.com/papers/696b2696d2a12237a9349db7https://doi.org/10.1039/d5md00910c
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