What question did this study set out to answer?

This research aims to synthesize and evaluate the anticancer properties of pyrazoline-thiophene hybrids.

January 17, 2026RSC Medicinal Chemistry8 citations

Exploring Pyrazoline-Thiophene Hybrids as CDK2 Inhibitors: Synthesis, Mechanistic, Biological Studies, and Computational Insights

HAHeba M. AbosalimTanta University TETarek ElmoselhyTanta University NSNabaweya SharafeldinTanta University

Key Points

This research aims to synthesize and evaluate the anticancer properties of pyrazoline-thiophene hybrids.
Synthesis of pyrazoline-linked thiophene compounds.
Assessment of anticancer potential through biological studies.
Evaluation of mechanistic pathways influencing efficacy.
Computational modeling to predict interactions with CDK2.
Identified bis-thiophene compounds (4n and 4o) as the most effective analogues.
Tris-thiophene compound (4p) also showed significant anticancer activity.
Mechanistic studies revealed insights into pathways affected by these compounds.

Abstract

Pyrazoline-linked thiophene (4a-p), a novel family of compounds, was designed and synthesized, and its anticancer potential was assessed. The most effective analogues of bis-thiophene (4n and 4o) and tris-thiophene (4p)...

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Cite This Study

Abosalim et al. (2026) studied this question.

synapsesocial.com/papers/696b2696d2a12237a9349db7 https://doi.org/10.1039/d5md00910c

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January 17, 2026RSC Medicinal Chemistry8 citations

Exploring Pyrazoline-Thiophene Hybrids as CDK2 Inhibitors: Synthesis, Mechanistic, Biological Studies, and Computational Insights

View Full Paper

HAHeba M. AbosalimTanta University TETarek ElmoselhyTanta University NSNabaweya SharafeldinTanta University

Key Points

This research aims to synthesize and evaluate the anticancer properties of pyrazoline-thiophene hybrids.
Synthesis of pyrazoline-linked thiophene compounds.
Assessment of anticancer potential through biological studies.
Evaluation of mechanistic pathways influencing efficacy.
Computational modeling to predict interactions with CDK2.
Identified bis-thiophene compounds (4n and 4o) as the most effective analogues.
Tris-thiophene compound (4p) also showed significant anticancer activity.
Mechanistic studies revealed insights into pathways affected by these compounds.

Abstract

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Cite This Study

Abosalim et al. (2026) studied this question.

synapsesocial.com/papers/696b2696d2a12237a9349db7 https://doi.org/10.1039/d5md00910c

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