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February 25, 2026RSC Advances4 citationsOpen Access

Development of new pyrazole–thiophene hybrids: synthesis, anticancer assessment, and molecular docking insights

SSSonia SamySMSamar E. MahmoudEAEbrahim Abdel‐Galil

Key Points

  • The study aims to evaluate the anticancer properties of novel pyrazole–thiophene hybrids and their pharmacokinetic profile.
  • Synthesis of new pyrazole–thiophene hybrids
  • Assessment of anticancer potential using biological assays
  • Structure-activity relationship (SAR) analysis
  • In silico molecular docking studies
  • Pharmacokinetic profiling using SwissADME program
  • New hybrids demonstrated significant anticancer activity
  • SAR analysis revealed key structural features contributing to efficacy
  • Molecular docking provided insights into target interactions
  • Pharmacokinetic profile indicated favorable drug-like properties

Abstract

The anticancer potential, SAR, and in silico studies of novel pyrazole–thiophene hybrids were assessed; also, a pharmacokinetic profile using the SwissADME program was performed.

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Cite This Study

Samy et al. (2026) studied this question.

synapsesocial.com/papers/699e9106f5123be5ed04e449https://doi.org/10.1039/d6ra00429f
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