What question did this study set out to answer?

This study aims to evaluate techniques for elemental mapping in biological samples using high-resolution methods.

January 18, 2026Journal of Analytical Atomic Spectrometry0 citationsOpen Access

Substrate and standard evaluation for correlative elemental mapping of biological samples by X-ray fluorescence microscopy and laser ablation ICP-MS

DZDavid Z. ZeeMichigan State University SASoo Hyun AhnMichigan State University ACAndrew M. CrawfordMichigan State University

Key Points

This study aims to evaluate techniques for elemental mapping in biological samples using high-resolution methods.
Utilized x-ray fluorescence microscopy for detailed elemental mapping of samples.
Employed laser ablation ICP-MS for precise elemental analysis.
Conducted comparative analysis of the two techniques.
Assessed the effectiveness of substrate materials for both methods.
Demonstrated superior sensitivity and resolution in elemental mapping with x-ray fluorescence microscopy.
Laser ablation ICP-MS provided complementary data, enhancing the overall understanding of sample composition.

Abstract

Analytical techniques that offer accurate, sensitive, and high-resolution elemental mapping have significantly advanced our understanding of the role of inorganic chemistry in vital biological processes.

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