ABSTRACT The aging of the hematopoietic system is central to physiological aging, with profound consequences for immune competence, tissue regeneration, and systemic health. Age‐related changes manifest as altered blood cell composition, functional decline in hematopoietic stem cells (HSCs), and deterioration of the bone marrow niche. Beyond hematologic dysfunction, hematopoietic aging acts as a systemic amplifier of age‐related diseases through clonal hematopoiesis and inflammatory remodeling. This review integrates recent insights into the mechanisms and systemic impacts of hematopoietic aging, reframing it as a modifiable axis of systemic aging. We highlight emerging rejuvenation strategies—senolytics, metabolic reprogramming, and microbiota‐targeted therapies—that aim to restore hematopoietic and immune function, offering promising avenues to improve healthspan and reduce age‐related multimorbidity.
Miyawaki et al. (Fri,) studied this question.
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