Elucidating the molecular mechanism of Bazhen decoction in the treatment of liver cancer: an integrated approach using network pharmacology, cancer databases, molecular docking, and experimental validation.

Key Points

• This research aims to explain how Bazhen decoction affects liver cancer through various molecular mechanisms.
• Utilized network pharmacology to identify key molecular targets.
• Analyzed data from cancer databases to investigate pathways involved in liver cancer.
• Performed molecular docking studies to assess the binding affinity of Bazhen decoction compounds.
• Validated findings through experimental approaches to confirm the effects on liver cancer cells.
• Bazhen decoction regulates multiple targets including AKT1, PIK3CA, SRC, and HSP90AA1.
• Demonstrated suppression of the PI3K-AKT signaling pathway.
• Findings support its potential use in clinical liver cancer therapies.