Elucidating the molecular mechanism of Bazhen decoction in the treatment of liver cancer: an integrated approach using network pharmacology, cancer databases, molecular docking, and experimental validation.

January 16, 2026

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Key Points

This research aims to explain how Bazhen decoction affects liver cancer through various molecular mechanisms.
Utilized network pharmacology to identify key molecular targets.
Analyzed data from cancer databases to investigate pathways involved in liver cancer.
Performed molecular docking studies to assess the binding affinity of Bazhen decoction compounds.
Validated findings through experimental approaches to confirm the effects on liver cancer cells.
Bazhen decoction regulates multiple targets including AKT1, PIK3CA, SRC, and HSP90AA1.
Demonstrated suppression of the PI3K-AKT signaling pathway.
Findings support its potential use in clinical liver cancer therapies.

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Integrated approach uncovers Bazhen decoction's anti-liver cancer effects, suggesting clinical potential.

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Wang et al. (2026) studied this question.

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