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This research aims to evaluate the effects of TDP-43 overexpression in oxytocin neurons on cell population and behavior in mice.

January 23, 2026Neuropathology and Applied Neurobiology0 citationsOpen Access

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Analyses of the Effects of Wild‐Type TDP‐43 Overexpression in Oxytocin Neurons in Mice

SBSofia BerghLund University OSOskar SimonssonLund University ÅPÅsa PetersénLund University

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This research aims to evaluate the effects of TDP-43 overexpression in oxytocin neurons on cell population and behavior in mice.
Selective overexpression of TDP-43 conducted using AAV in oxytocin neurons
Comparison made with uninjected mice
Analysis of oxytocin-immunopositive cell counts
TDP-43 overexpression leads to a decrease in oxytocin-immunopositive cells
No significant behavioral or metabolic changes observed in mice due to the overexpression

Abstract

ABSTRACT Selective TDP‐43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin‐immunopositive cells compared to uninjected mice. AAV‐mediated TDP‐43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.

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Analyses of the Effects of Wild‐Type TDP‐43 Overexpression in Oxytocin Neurons in Mice

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