What question did this study set out to answer?

The research aims to explore how chirality affects the suppression of tumour cells through a bio-interface.

January 23, 2026Materials Chemistry Frontiers0 citations

Supramolecular Enantioselective Transfer Amino Acid @pillar5arene Bio-interface for Effective Tumour Cells Suppression

XMXiaowei MaoJianghan University YLYuchao LiuQingdao University of Science and Technology YWYue WangSecond Military Medical University

Key Points

The research aims to explore how chirality affects the suppression of tumour cells through a bio-interface.
Utilized a supramolecular approach to create a bio-interface with amino acids.
Investigated the enantioselective properties of pillar[5]arene compounds.
Conducted in vitro tests to assess the efficacy against tumour cells.
Demonstrated significant suppression of tumour cell growth with enantioselective compounds.
Highlighted the crucial role of chirality in biological activity against cancer.
Showed enhanced effectiveness compared to non-enantioselective variants.

Abstract

Chirality is a fundamental feature of living organisms, playing an essential role in biological and physiological processes that are closely related to the fate of cancer cells. It is challenging...

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