What question did this study set out to answer?

To investigate the frequency and activation status of mucosal-associated invariant T cells in dermatomyositis.

January 23, 2026Clinical and Experimental Rheumatology0 citations

Alterations of mucosal-associated invariant T cells in dermatomyositis

SYSiyuan YeZhejiang Sci-Tech University JDJun DuTianjin Medical University General Hospital YZYing ZhangNorth China University of Science and Technology

Key Points

To investigate the frequency and activation status of mucosal-associated invariant T cells in dermatomyositis.
Analyzed the frequency of MAIT cells in dermatomyositis patients.
Examined the secretion levels of IFN-γ by MAIT cells.
Correlated MAIT cell alterations with clinical features of dermatomyositis.
MAIT cells were found to be reduced in frequency in patients with dermatomyositis.
There was increased secretion of IFN-γ by MAIT cells in dermatomyositis cases.
The findings suggest a potential role of MAIT cells in the disease's development.

Abstract

The reduced frequency of MAIT cells in DM may be associated with excessive activation. The increased secretion of IFN-γ by MAIT cells may contribute to DM pathogenesis.

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