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January 24, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

NF-κB (p65, p50), IL-18, and IL-10 as Therapeutic Targets in Prostate Cancer and BPH: Molecular Insights into Inflammation-Driven Pathogenesis

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SDShailendra DwivediSSSapna SainiAPAjay Panwar

Key Points

  • The aim is to explore the roles of NF-κB, IL-18, and IL-10 as therapeutic targets in prostate cancer and benign prostatic hyperplasia (BPH).
  • Analysis of NF-κB and its associated cytokines in prostate cancer and BPH samples.
  • Evaluation of cytokine levels as noninvasive biomarkers for diagnosis and staging.
  • Investigation of the relationship between environmental factors and biomarker expression.
  • NF-κB activity correlates with IL-18 and IL-10 levels in prostate tissues.
  • Cytokine profiles were distinct between prostate cancer and BPH cases.
  • IL-18 and IL-10 show potential for noninvasive diagnosis and risk assessment.

Abstract

NF-κB and its downstream cytokines, IL-18 and IL-10, may serve as inflammation-driven, noninvasive biomarkers for prostate cancer diagnosis, staging, and risk stratification, particularly in populations exposed to environmental factors.

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Cite This Study

Dwivedi et al. (2026) studied this question.

synapsesocial.com/papers/69746090bb9d90c67120a5cdhttps://doi.org/10.31557/apjcp.2026.27.1.381
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