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January 24, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

NF-κB (p65, p50), IL-18, and IL-10 as Therapeutic Targets in Prostate Cancer and BPH: Molecular Insights into Inflammation-Driven Pathogenesis

SDShailendra DwivediBaba Raghav Das Medical College SSSapna SainiBaba Raghav Das Medical College APAjay PanwarDR. B.R.A. Institute Rotary Cancer Hospital

Key Points

The aim is to explore the roles of NF-κB, IL-18, and IL-10 as therapeutic targets in prostate cancer and benign prostatic hyperplasia (BPH).
Analysis of NF-κB and its associated cytokines in prostate cancer and BPH samples.
Evaluation of cytokine levels as noninvasive biomarkers for diagnosis and staging.
Investigation of the relationship between environmental factors and biomarker expression.
NF-κB activity correlates with IL-18 and IL-10 levels in prostate tissues.
Cytokine profiles were distinct between prostate cancer and BPH cases.
IL-18 and IL-10 show potential for noninvasive diagnosis and risk assessment.

Abstract

NF-κB and its downstream cytokines, IL-18 and IL-10, may serve as inflammation-driven, noninvasive biomarkers for prostate cancer diagnosis, staging, and risk stratification, particularly in populations exposed to environmental factors.

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