Computational Analysis and in vitro Validation of the Anti-Prostate Cancer Activity of Sesamin from Sesamum indicum.

Key Points

• This research aims to evaluate the anti-prostate cancer properties of sesamin derived from sesame seeds.
• Conducted computational analysis of sesamin's properties.
• Performed in vitro validation using DU145 prostate cancer cells.
• Investigated mechanisms of action, focusing on G1-phase effect.
• Sesamin shows strong antiproliferative activity against DU145 cells.
• Induces pro-apoptotic effects, facilitating cancer cell death.
• Operates through a p53-independent pathway, suggesting a novel therapeutic approach.