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This research aims to evaluate the protective effects of Prunus amygdalus var. amara essential oil against morphine-induced cell death.

January 24, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

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The Effect of Prunus amygdalus var. amara Essential Oil on Suppressing Morphine-Induced Cell Death via Inhibition of Inflammatory Cytokines and Nitric Oxide Production

ZDZhila DinariRazi University HZHossein ZhalehBu-Ali Sina University

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This research aims to evaluate the protective effects of Prunus amygdalus var. amara essential oil against morphine-induced cell death.
In vitro assessment using PC12 neuronal cells
Treatment with Prunus amygdalus var. amara essential oil
Analysis of nitric oxide production and apoptosis markers
Essential oil reduces cell death caused by morphine
Inhibition of nitric oxide production observed
Caspase-3 activity decreased, indicating reduced apoptosis
Mitochondrial membrane integrity improved

Abstract

Our findings indicate that the essential oil derived from Prunus amygdalus var. amara effectively mitigates cell death induced by morphine in PC12 cells. This essential oil demonstrates the ability to inhibit nitric oxide (NO) production. Furthermore, it appears to impede apoptosis by inhibiting Caspase-3 activity, preventing DNA fragmentation, and disrupting the integrity of the mitochondrial membrane.

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The Effect of Prunus amygdalus var. amara Essential Oil on Suppressing Morphine-Induced Cell Death via Inhibition of Inflammatory Cytokines and Nitric Oxide Production

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Abstract

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