Does sod1 encode a molecular clock? Mutations that mimic asparagine deamidation inhibit heterodimerization with ALS-mutant SOD1

Key Points

• The study investigates whether mutations in SOD1 affect its ability to form heterodimers, particularly in relation to ALS.
• Examined mutations that mimic asparagine deamidation
• Analyzed protein-protein interaction through self-exchange of subunits
• Evaluated effects on heterodimerization with ALS-mutant SOD1
• Mutations that mimic asparagine deamidation inhibit heterodimerization with ALS-mutant SOD1
• Altered interactions affect the molecular functions of SOD1
• Findings suggest implications for understanding sporadic ALS mechanisms