This abstract presents the protocol for a randomized trial comparing tailored biliopancreatic limb length (40% of total small bowel length) to a standard 180 cm limb, with no results reported yet.
RCT (n=500)
randomized
Yes
Does tailoring the biliopancreatic limb length to 40% of total small bowel length improve total weight loss after one year in patients undergoing one anastomosis gastric bypass compared to a standard 180 cm limb?
This study protocol outlines a randomized controlled trial to determine if tailoring biliopancreatic limb length to 40% of total small bowel length improves weight loss outcomes in one anastomosis gastric bypass.
Abstract Background One Anastomosis Gastric Bypass (OAGB) is the most common bariatric and metabolic surgery (MBS) in Israel, recognized for its effectiveness in achieving sustainable weight loss and mitigating obesity-related diseases. The metabolic outcomes of OAGB are significantly influenced by the length of the biliopancreatic limb (BPL), with evidence suggesting that longer BPLs yield satisfactory outcomes. Objective This study aims to determine whether tailoring the BPL length to the total small bowel length (TSBL) results in more effective weight loss compared to patients undergoing standard bypass with a fixed BPL of 180 cm. We will also evaluate the efficacy and safety of this approach, ensuring it does not lead to long-term morbidity or negatively impact patients’ quality of life. Methods This multicentre, prospective, randomized trial will enrol 500 participants across three centres: one public hospital and two private hospitals in Israel. Participants aged 18 and older will be randomized into two groups: one group will receive a tailored BPL length based on total small bowel length (40%), while the control group will receive a standard BPL of 180 cm. The primary endpoint is total weight loss after one year. Secondary endpoints include postoperative complications, quality of life, and improvements in obesity-related diseases. The study was registered on clinicaltrials.gov, and patient recruitment has begun. Results During this presentation, we will review current literature on BPL tailoring in gastric bypass procedures and share our initial experiences, including preliminary findings from the initial phase of the study, highlighting recruitment progress and feedback from participants. Conclusion This study presents the protocol of the tailored BPL to 40% of TSBL (TABLE-40 study).
Ahmad et al. (Thu,) conducted a rct in Obesity (n=500). Tailored biliopancreatic limb length (40% of total small bowel length) vs. Standard biliopancreatic limb of 180 cm was evaluated on Total weight loss after one year. This abstract presents the protocol for a randomized trial comparing tailored biliopancreatic limb length (40% of total small bowel length) to a standard 180 cm limb, with no results reported yet.