The bimodal edema phenomenon after myocardial ischemia/reperfusion consists of an initial wave due to reperfusion and a second wave related to tissue healing processes.
The two waves of post-ischemia/reperfusion edema are driven by distinct mechanisms: reperfusion injury initially, followed by tissue healing processes.
The 2 waves of the post-I/R edematous reaction are related to different pathophysiological phenomena. Although the first wave is secondary to reperfusion, the second wave occurs mainly because of tissue healing processes.
Fernández‐Jiménez et al. (2015) studied this question. The bimodal edema phenomenon after myocardial ischemia/reperfusion consists of an initial wave due to reperfusion and a second wave related to tissue healing processes.