PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 2, 2026European journal of medical research1 citationsOpen Access

Identification of the biomarkers associated with lipid metabolism and endoplasmic reticulum stress in pediatric sepsis through bioinformatics analysis and quantitative reverse transcriptase PCR (qRT-PCR) assay

View Full Paper
BSBaoju ShanChongqing UniversityJCJiaoyang CaoChongqing UniversityTYTing YangChongqing University

Key Points

  • The aim is to identify biomarkers associated with lipid metabolism and endoplasmic reticulum stress in pediatric sepsis.
  • Utilized bioinformatics analysis to identify potential biomarkers.
  • Conducted quantitative reverse transcriptase PCR (qRT-PCR) to validate findings.
  • Identified four key biomarkers: ACER3, DGAT2, GBA, and TSPO.
  • These biomarkers are linked to lipid metabolism and endoplasmic reticulum stress in pediatric sepsis.
  • Findings provide insights into potential treatment strategies for pediatric sepsis.

Abstract

A total of 4 biomarkers (ACER3, DGAT2, GBA, and TSPO) related to lipid metabolism and endoplasmic reticulum stress in pediatric sepsis were identified. These biomarkers offered fresh insights into the mechanisms and therapeutic approaches of pediatric sepsis.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Shan et al. (2026) studied this question.

synapsesocial.com/papers/6980fd18c1c9540dea80ed32https://doi.org/10.1186/s40001-026-03931-x
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DGAT2 Plays a Crucial Role to Control ESRRAPROX1 Transcriptional Network to Maintain Hepatic Mitochondrial Sustainability2024 · 5 citations
  2. 2clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters2012 · 39,542 citations
  3. 3Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential2011 · 255 citations
  4. 4Ligand docking and binding site analysis with PyMOL and Autodock/Vina2010 · 2,677 citations
  5. 5Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins2019 · 89 citations