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February 2, 2026Organic & Biomolecular Chemistry2 citations

Total Synthesis of (ent)-Linderolide E and (ent)-15-Hydroxy-and 15-Acetoxyisogermafurenolides, and Structural Revision of (ent)-Linderolide E

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ASAnisha SureshMSMahendra R. ShingoleKKKrishna P. Kaliappan

Key Points

  • This research aims to achieve the total synthesis of specific sesquiterpenoids and revise their structures.
  • Conducted total synthesis of (ent)-linderolide E and (ent)-15-hydroxy- and 15-acetoxyisogermafurenolides.
  • Performed structural analysis to confirm revisions of (ent)-linderolide E.
  • Successfully synthesized the targeted sesquiterpenoid compounds.
  • Provided structural revisions that clarify the configuration of (ent)-linderolide E.

Abstract

Sesquiterpenoid scaffolds such as the eudesmane-type linderolides and elemanolide-type isogermafurenolides remain synthetically challenging despite their structural interest and documented biological activities. While prior studies have addressed the parent isogermafurenolide through...

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Cite This Study

Suresh et al. (2025) studied this question.

synapsesocial.com/papers/6980fdc7c1c9540dea80f6bdhttps://doi.org/10.1039/d6ob00001k
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