Elevated serum indoxyl sulfate levels were independently associated with increased aortic stiffness in kidney transplant recipients (p=0.017).
Observational (n=94)
Are elevated serum indoxyl sulfate levels associated with increased aortic stiffness in kidney transplant recipients?
Elevated serum indoxyl sulfate levels are independently associated with increased aortic stiffness in kidney transplant recipients, highlighting the role of residual uremic toxins in post-transplant vascular aging.
p-value: p=0.017
Although kidney transplantation (KT) restores renal function, residual uremic toxins, such as indoxyl sulfate (IS), may persist and contribute to vascular remodeling and aging. Aortic stiffness, reflected by carotid–femoral pulse wave velocity (cfPWV), is a strong predictor of cardiovascular events. This study enrolled KT recipients to examine the association of circulating IS with aortic stiffness. Using the SphygmoCor system, we assessed aortic stiffness, which was defined as cfPWV > 10 m/s. Serum IS concentrations were measured by liquid chromatography–tandem mass spectrometry. Of 94 KT recipients, 26 (27.7%) met the criteria for aortic stiffness. Compared with patients without aortic stiffness, those with aortic stiffness were older (p = 0.017) and had significantly higher systolic blood pressure (p = 0.011) and fasting glucose levels (p = 0.002), a higher prevalence of diabetes (p = 0.043), and higher IS levels (p = 0.002). According to multivariable logistic regression, serum IS remained independently associated with aortic stiffness (p = 0.017). According to stepwise linear regression, log-transformed IS further showed a positive correlation with cfPWV (p = 0.016). Serum IS remained an independent determinant of aortic stiffness in KT recipients, highlighting the burden of residual uremic toxins as a contributor to post-transplant vascular aging.
Yang et al. (Fri,) conducted a observational in Kidney transplantation (n=94). Elevated serum indoxyl sulfate (IS) levels vs. Lower serum indoxyl sulfate levels was evaluated on Aortic stiffness (carotid-femoral pulse wave velocity > 10 m/s) (p=0.017). Elevated serum indoxyl sulfate levels were independently associated with increased aortic stiffness in kidney transplant recipients (p=0.017).