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The research aims to investigate the effects of co-delivering synaptogenic and angiogenic nanoparticles on synapse formation after ischemic stroke.

February 2, 2026Journal of Materials Chemistry B0 citationsOpen Access

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Co-Delivery of Synaptogenic and Angiogenic Nanoparticles in MAP Scaffolds Enhances Post-Stroke Synapse Formation

NPNhi Van PhanDuke University JTJeremy Lee ThomasDuke University APAiden PasinskyDuke University

Key Points

The research aims to investigate the effects of co-delivering synaptogenic and angiogenic nanoparticles on synapse formation after ischemic stroke.
Used MAP scaffolds to deliver nanoparticles
Administered synaptogenic and angiogenic nanoparticles together
Assessed synapse formation in post-stroke models
Enhanced synapse formation observed in treated models
Improved motor function recorded post-intervention
Demonstrated potential for better recovery outcomes

Abstract

Ischemic stroke remains one of the leading causes of long-term disability worldwide, depriving patients of their quality of life and physical independence. The root cause of this loss of motor...

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Co-Delivery of Synaptogenic and Angiogenic Nanoparticles in MAP Scaffolds Enhances Post-Stroke Synapse Formation

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