P300 enhances glycolysis and dox resistance in DLBCL by upregulating HK2 expression through histone lactylation

Key Points

• The study aims to investigate how P300 contributes to doxorubicin resistance in DLBCL through its role in glycolysis.
• Examined the role of P300 in DLBCL cell lines.
• Analyzed the glycolysis pathway and its regulation by P300.
• Studied the expression levels of HK2 and its relationship with histone lactylation.
• P300 was found to enhance glycolysis in DLBCL cells.
• Increased HK2 expression was linked to P300 activity.
• Dox resistance was correlated with the upregulation of glycolytic pathways.