What question did this study set out to answer?

This research focuses on understanding ketamine's effects on depression and its potential for misuse.

February 5, 2026Substance Use & Misuse0 citations

The Emerging Crisis in Non-Prescribed Ketamine Use: A Rapid Attenuation of Depression in Face of Abuse and “Chill-out” or Escapism Drug

KLKai Uwe Lewandrowski KBKenneth BlumEötvös Loránd University SSSergio SchmidtHospital Universitário Gaffrée e Guinle

Key Points

This research focuses on understanding ketamine's effects on depression and its potential for misuse.
Reviewed ketamine's mechanism of action in treating depression
Examined the risks associated with non-prescribed use
Outlined the implications for regulatory frameworks
Ketamine shows rapid effects in alleviating depression symptoms
Concerns arise regarding its psychoactive properties and potential for abuse
Regulatory measures are needed to manage misuse risks

Abstract

Elucidating ketamine's mechanism of action may inform the development of next-generation psychoplastogens that promote neural plasticity in TRD and unipolar MDD. However, ketamine's psychoactive properties and abuse potential, along with concerns regarding misuse and diversion, underscore the need for enhanced clinical oversight and regulatory frameworks.

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Cite This Study

Lewandrowski et al. (Sun,) studied this question.

synapsesocial.com/papers/69843371f1d9ada3c1fb08ec https://doi.org/https://doi.org/10.1080/10826084.2025.2612330

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